Transcribed
Growth hormone releasing cheme: how it's controlled
GROWTH HORMONE Hypothalamus GHRH - Growth Hormone Releasing Hormone GH - Growth Hormone IGF-1- Insulin-like Growth Factor Somatostatin GHRH Pituitary gland GH Ghrelin IGF-1
Growth hormone releasing cheme: how it's controlled
shared by hghtherapydoc on Feb 24
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So, as it appears Growth hormone release is not continuous; it is released in a number of ‘bursts’ or pulses every three to five hours. And production of Human Growth Hormone (HGH) is controlled b...
y two other hormones that are released from the hypothalamus (a part of the brain): growth hormone-releasing hormone (GHRH), which stimulates the pituitary to release growth hormone, and somatostatin, which inhibits that release.
In addition, Insulin-like Growth Factor I (IGF-I) inhibits GH secretion by a negative loop at both hypothalamic and pituitary levels. GH acts both directly through its own receptors and indirectly through the induced production of IGF-I.
Their effects may be synergistic (stimulate growth) or antagonistic, as for the effect on glucose metabolism: GH stimulates lipolysis and promotes insulin resistance, whereas IGF-I acts as an insulin agonist.
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