Genetics and IBD

23andMe Genetics and IBD With Inflammatory Bowel Disease (IBD) on the rise, there are millions invested in research, dozens of studies being conducted and now genetic data being collected to help reveal the complexities of the disease. What is IBD? A chronic autoimmune disorder that results in inflammation of the digestive tract causing abdominal cramps, diarrhea, pain, fever and weight loss. Crohn's disease Ulcerative colitis It's on the rise. The incidence and prevalence of IBD are increasing with time and in different regions around the world, indicating its emergence as a global disease. 2 out of every 1,000 people are affected by ulcerative colitis; a higher incidence is seen in people with European or Jewish ancestry. .2% 1.4M Today, more than 1.4 million Americans Crohn's rates are rising in Asian countries with traditionally low rates of the disease, suffer from Crohn's disease or ulcerative colitis. including China. Genetics play a role in IBD. iiiii 20% An estimated Up to 50-60% of Crohn's of affected disease is due individuals will have to heritability". family history of IBD. Since 2001, scientists have published approximately POPORePIO.OOeDDÚ 1,300 studies about the genetics of IBD. We just launched our own: 23andMe IBD Study In 2014 we launched a partnership with Pfizer to learn how genes and environment could play a role in IBD drug treatment, and how they relate to IBD risk and progression. 23andMe.com/IBD Genetic data can be used for good. *Meaning that genetics contributes slightly more to the differences in risk across a population than environmental factors. Sources: ncbi.nlm.nih.gov/pmc/articles/PMC2746333/#!po=13.6364 | ncbi.nlm.nih.gov/pubmed/21530736 | medscape.com/viewarticle/756899 | ccfa.org/assets/pdfs/ibdfactbook.pdf | mountsinai.org/about-us/newsroom/press-releases/researchers-discover-five-genetic-markers-of-crohns-disease-in-jews-of-european-descent | cdc.gov/ibd/ onlinelibrary.wiley.com/doi/10.1002/ibd.20352/pdf | my.clevelandclinic.org/disorders/inflammatory_bowel_disease_ibd/hic_genetic_aspects_of_inflammatory_bowel_disease.aspx | ncbi.nlm.nih.gov/pubmed/17068223 | ncbi.nlm.nih.gov/pubmed?cmd3Search&term=17200669 | ncbi.nlm.nih.gov/pubmed?cmd3DSearch&term=17554300 | ccfa.org/ ncbi.nlm.nih.gov/pmc/articles/PMC3491803/ | ncbi.nlm.nih.gov/pubmed/22497584 | ncbi.nlm.nih.gov/pubmed/?term=inflammatory+bowel+disease+genetics+review