Stem Cell Research. The History

Stem Cell Research. A History 2007 2011 1960s • Joseph Altman and Gopal Das present scientific: • June 2007: Research reported by three different groups shows that normal skin cells can be repro- grammed to an embryonic state in mice.[84] In the same month, scientist Shoukhrat Mitalpov reports the first PlacidWay • Israeli scientist Inbar Friedrich O Russia 2005 Ben-Nun led a team which produced the first stem cells • Researchers at UC Irvine's Reeve-rvine from endangered species, a FodeWoy breakthrough that could save animals in danger of extinction. O ISRAEL evidence of adult Research Center are able to partially restore the ability of rats with paralyzed spines to walk through the injection of human neural stem cells. Canada O England O O Germany Holland successful creation of a primate stem cell line through somatic cel nuclear transfer. neurogenesis, ongoing stem cell activity in the brain: their reports con- tradict Cajals "no neurons" OJapan O USA USA O Israel O O USA 2008 2012 2010 • 11 October 2010 First trial of embryonic stem cells in humans. new largely ignored. dogma and are • Katsuhiko Hayashi used mouse skin cells to create stem cells and then used these stem cells to create mouse eggs. These eggs were then fertilized and produced healthy baby offspring. These latter mice were able to have their own babies. • January 2008: Robert Lanza and colleagues at Advanced 1981 Cell Technology and UCSF create the first human embry- onic stem cells without destrUc- O USA 1963 2006 1992 • Neural stem cells are cultured in vitro as neurospheres. 1908 • McCulloch and Till illustrate the Mouse embry- onic stem cells are • April 2006 Scientists at the at University of llinois Chicago identified novel tion of the embryo. OUSA • The term "stem was for 2005 • Researchers at Kingston • 25 October 2010: Ishikawa et al. write in the Journal of Experi- mental Medicine that research cell" presence of self- derived from the inner cell mass by scientists Evans, Kaufman, and Gail renewing cells in mouse O JAPAN stem cells from the umbili- cal cord blood with embry- onic and hematopoietic characteristics. OUSA proposed scientific use by the Russian histolo- Martin University in England claim to have discovered a third category of stem cell, shows that transplanted cells that contain their new host's marrow. O CANADA bone 1995 • Dr. B.G. Matapurkar pioneers in adult stem-cell 2001 • October 2008: Sabine Conrad and colleagues at Tübingen, 2009 Matthew 1998 • John Gearhart (Johns Hopkins extracted germ cells from gist Alexander nuclear DNA could still be inviduals immune system due to foreign Maksimov (1874- 1928) at congress Martin. R. Martin is attributed 2013 Gail Germany generate pluripotent stem cells from spermatogonial cord-blood- embryonic-like stem cells (CBES), derived from umbilical cord blood. • January 2009: Yong Zhao and colleagues confirmed the reversal caused type1 diabetes by Cord Blood-Derived Multipo- tent Stem Cells (CB-SCs) in an animal experiment. dubbed rejected by the 1968 Bone marrow research with clinical utilization of research in the body neo-regener body. Received International Patent from US Patent • Scientists at Advanced Cell Technology clone first early (four- to six-cell stage) human embryos for the • October 2006: Scientists at Newcastle University in England create the first of hematologic for coining the University) First time lab grown made from muscle stem-cells been cooked and tasted. derived cells of adult human testis by of autoimmune- Tissues made from a person's stem cells ion of tissues DNA. 2003 • Dr. Songtao Shi of NIH society in Berlin. It "Embryonic term in the mitochondrial meat fetal (primordial before developing pluripo- tent stem cell lines from the original extract. culturing the cells in vitro under leukemia inhibitory factor (LIF) supplementation. postulated exis- tence of haema- topoietic gonadal tissue cells) Stem Cell". could therefore be rejected, mitochondrial Office (USA) in 2001 (effective from 1995). Cinical utilization in human body also demonstrated and pat- ented in 60 patients (World Journal of Surgery-1999 and 1991. The group claims these cells are able to differenti- ate into more types of tissue ever artificial liver cells using umbilical cord blood between siblings successfully treats SCID. transplant two purpose of generating embryonic stem cells. has discovers new source of adult stem cells in children's primary teeth. germ stem O ENGLAND because O GERMANY genomes tend to accumulate O USA cells. stem cells. than adult stem cells. O ENGLAND O ENGLAND O USA mutation O RUSSIA O USA O USA O USA O HOLLAND 1980 2000 2006 2010 1960 1990 www.PlacidWay.com [email protected] +1.303.500.3821