The Newest Drugs On The Market

The Newest DRUGS on the Market 20 Drugs on the Market New Prescription NESINA OSPHENA (Alogliptin) To improve blood sugar control in adults with type 2 diabetes. (Ospemifene) To treat women experiencing moderate to severe dyspareunia (pain during sexual intercourse) a symptom of vulvar and vaginal atrophy due to menopause. POMALYST (Pomalidomide) K To treat patients with multiple myeloma whose disease progressed after being treated with other cancer medication. LYMPHOSEEK (Technetium Te 99m tilmanocept) A radioactive diagnostic imaging agent that helps doctorslocate lymph nodes in patients with breast cancer or melanoma who are undergoing surgery to remove tumor-draining lymph nodes. KYNAMRO (mipomersen sodium) To treat patients with a rare type of high cholesterol called homozygous familial hypercholesterolemia (HOFH). DOTAREM (Gadoterate meglumine) For use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years+. KADCYLA (ado-trastuzumab emtansine) For patients with HER2-positive, late-stage (metastic) breast cancer. TECFIDERA (Dimethyl Fumarate) To treat adults with relapsing forms of multiple sclerosis (MS). INVOKANA (Canagliflozin) Used with diet and exercise, to improve glycemic control in adults with type 2 diabetes. BREO ELLIPTA (Fluticasone furoate and vilanterol inhalation powder) For the long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and'or emphysema. BRINTELLIX (Vortioxetine) To treat adults with major depressive disorders. XOFIGO (Radium „Ra 223 dichloride) To treat men with symptomatic late-stage (metastic) castration-resistant prostate cancerthat has spread to bones but not to other organs. DUAVEE TAFINLAR (Dabrafenib) To treat patients with melanoma whose tumors express the BRAF V600E gene mutation. (Conjugated estrogens/bazedoxifene) To treat moderate-to-severe hot flashes (vasomotor symptoms) associated with menopause and to prevent osteoporosis after menopause. MEKINIST ADEMPAS (Trametinib) To treat patients whose tumors express the BRAF V600E or V600K gene mutations. (Riociguat) To treat adults with forms of pulmonary hypertension. OPSUMIT GILOTRIF (Macitentan) To treat adults with pulmonary arterial hypertension (PAH), a chromic, progressive and debilitating disease that can lead to death or the need for lung transplantation. (Afatinib) For patients with late stage (metastatic) non- small cell lung cancer (NSCLC) whose tumors express specific types of epidermal growthfactor receptor (EGFR) gene mutations, as detected by an FDA approved test. VIZAMYL TIVICAY 15 (Dolutegravir) (Flutemetamol F 18 injection) A radioactive diagnostic drug for use with positron emission tomography (PET)imaging of the brain in adults being evaluated for Alzheimer's disease (AD) and dementia. To treat HIV-1 infection. 10 New Illicit Drugs SALTS BATH SALTS E-CIGARETTES N-BOMB •"Ivory Wave," "Purple Wave," Vanilla Sky." and "Bliss" are among the many street names of so-called designer drugs known as "bath salts," which have sparked thou- sands of calls to poison centers across the U ingly ponutes len ras- operated devices mar- keted as a safer alterna- tive to smoking conven- tional cigarettes • Also called "legal acid," "smiles," or "251," they are generally found as powders, liquids, soaked into blotter paper (like LSD) or laced on some- thing edible. •These drugs contain synthetic chemicals that are similar to amphet- amines. Some, but not all, of the chemicals used to make them are illegal. •They produce flavored nicotine aerosol that looks and feels like to- bacco smoke but without the tar or other chemicals • These chemicals act on serotonin receptors in the brain, like other halluci- nogens, but they are con- siderably more powerful even than LSD. produced by burning to- bacco leaves. *while e-cigarettes do not produce tobacco smoke, it is still unclear how safe they are. They still de- liver nicotine, which is a highly addictive drug. · At least 14 young people are reported to have died after taking 251- 25C- or 25B-NBOMe between March 2012 and April 2013 •The effects can include agitation, paranoia, hallu- cinations, chest pain, in- creased pulse, high blood pressure, and suicidal thinking/behavior •How Do People Take Bath Salts? "They snort it, shoot it, mix it with food and drink," Horowitz Also, vapor from some e-cigarette products has been found to contain known carcinogens and toxic chemicals. NEW PSYCHOACTIVE SUB- SYRUP, PURPLE DRANK, SIZZURP MOLLY STANCES (SYNTHETICS) • Drinking prescription- strength cough syrup containing codeine and promethazine mixed with soda was referenced fre- quently in rap music be- ginning in the late 90s and has now become in- creasingly popular among youth in several areas of the country • Molly-slang for "molecular-refers to the pure crystalline powder form of the club drug MDMA (3-4 methylene- dioxymethamphetamine), which in pill form is known as ecstasy. • (NPS) is a general term for drugs that are de- signed to produce similar effects to common illicit drugs such as cannabis, cocaine and ecstasy • Molly, which is usually purchased in capsules, has seen a surge in inter- est in the past few years • Manufacturers of these drugs use new chemicals to replace those that are banned and are constant- ly changing the chemical structure of the drugs to stay ahead of the law • Codeine and other opi- oids present a high risk of fatal overdose due to their effect of depressing the central nervous system, which can slow or stop the heart and lungs. • Users may be seeking out Molly to avoid the adulterants or substitutes known to be commonly found in pills sold as ec- stasy, such as caffeine, methamphetamine, and other harmful drugs. • Just because they are advertised as legal, doesn't mean they are safe. • Deaths from prescrip- tion opioid medications now outnumber overdose deaths from all other drugs (including cocaine and heroin) • However, news reports have reported "Molly capsules containing co- caine, heroin, and other substances. N8 MEPHEDRONE KROKODIL SUBOXONE • Mephedrone is a rela- tively new drug, and so far there is limited evi- dence of how widely it is • Suboxone, is an opiate painkiller that's often used to wean addicts off of more powerful opiates like heroin and hydroco- done. "Krokodil" is a home- made synthetic form of a heroin-like drug called desomorphine that is hade by combining co- deine tablets with various toxic chemicals including lighter fluid and industrial cleaners. used • Mephedrone (4-methyl- methcathinone) was orig- inally marketed as a plant fertiliser and 'research chemical' • A report from the Sub- stance Abuse and Mental Health Services Adminis- tration (SAMHSA) found that the number of emer- gency room visits involv- ing Suboxone had in- creased by a factor of 10 from 2005 to 2010. More • People who have used mephedrone describe the effects as being similar to ecstasy, and estimate that the effects last be- tween 2 and 4 hours. Some also say that the drug can be compulsive ('more-ish') to use, and can create a state of psy- chological dependence. •This extremely danger- ous mixture gets its name from the scaly, gray- green dead skin that forms at the site of an in- jection. •The flesh destroyed by krokodil becomes gan- grenous, and, in some cases, limb amputation has been necessary to save a user's life. than half of these visits were for recreational use of the drug. • Compulsive use can lead to side-effects in- cluding insomnia, invol- untary muscle clenching and hallucinations BUTANE HASH OIL • Also known as amber, honey, wax, ear wax and by its initials BHO, butane hash oil is a highly concentrated form of the active ingredient in marijuana • Use of BHO is known as "dabbing," because of the way the drug is in- gested: Users place a small dab of the sub- stance on a hot, metal surface, then inhale the resulting puff of smoke • The high is nothing like regular marijuana: It's not uncommon for people to lose consciousness after inhaling BHO fda.gov/drugs/developmentapprovalprocess/druginnovation/default.htm webmd.com/mental-health/features/bath-salts-drug-dangers drugabuse.gov/drugs-abuse/emerging-trends druginfo.adf.org.au/attachments/1043_ADF_FactSheet_LegalHighNPS081013.pdf druginfo.adf.org.au/drug-facts/mephedrone#sthash.GyuWuCUs.dpuf livescience.com/40072-new-street-drugs-concern-officials.html