The History of Phentermine Diet Pills

A Timeline Infographic by MyPhentermine.com THE HISTORY OF PHENTERMINE H Y D R OC HLO RID E WHAT IS PHENTERMINE HCL? PHENTERMINE HYDROCHLORIDE (PRONOUNCED FEN-TER-MEEN) IS A POPULAR ORAL PRESCRIPTION WEIGHT LOSS MEDICATION PRESCRIBED TO PATIENTS WHO ARE DIAGNOSED AS OBESE. IT IS AN FDA APPROVED APPETITE SUPPRESSANT THAT STIMULATES THE CENTRAL NERVOUS SYSTEM; THUS, ITS COMPOSITION IS VERY SIMILAR TO AN AMPHETAMINE. CONSISTING OF PHENYL-TERTIARY-BUTYLAMINE AND HYDROCHLORIDE, PHENTERMINE HCL MAY BE USED FOR VARIOUS PURPOSES BY CERTAIN PHYSICIANS. IT'S MAIN PURPOSE IS THE TREATMENT OF OBESITY AND IS TYPICALLY PRESCRIBED ALONGSIDE A DIET AND EXERCISE REGIMEN. IDENTIFICATION & ADMINISTERED PHENTERMINE TIMELINE MILLIGRAMS Yellow & Gray 15mg Approvals & Rejections IN THE LAST 62 YEARS Blue & White 30mg Early 1950s Phentermine was introduced - According to various 8ources, Phentermine was said to be the very first weight loss medica- tion in the United States that suppreeses appetite to assist the patient in consum- ing less calories by making them feel full. Studies predicted that Phentermine would be s0 popular after its release that it could easily managed a 50% market share within the diet pill industry. Blue Speckled 37.5mg r1959 1959 PHENTERMINE FIRST First approved by FDA - It was during this year that Phentermine HCL had re- APPROVED ceived its first approval from the Food and Drug Administration for short-term treatment of obesity as an appetite sup- pressant. Due to potentially harmful side effects, it wa8 constrained to 90 day ad- ministration period. BY THE FOOD & DRUG ADMINĪSTRATION Early 1970s 1950s PHENTERMINE 90 DAY LIMITED TO Phentermine HCL Released - It was at this point that Phentermine was available to the public.day administration period. FIFTY PERECENT POTENTIAL MARKET SHARE ADMINISTRATION PERIOD 1984 Fenfluramine + Phentermine = Fen-Phen - Around this time Fen-Phen was intro- duced by Michael Weintraub, M.D. and a group of collaborators from the University of Rochester Medical center. Their report revealed that combining both phentermine and Fenfluramine (or Dexfenfluramine) produced more effective resulte than taking either one by itself. Fenfluramine worke in the eame manner as that of Phentermine hcl - increasing serotonin (a neurotransmitter) levels causing the pa- tient to feel full, instead of craving food when hungry. Month 1 Month 2 Month 3 1990 - 1992 1= 30 Days 1= 30 Days 1= 30 Days Studies Monitoring Fen-Phen this long-term atudy, it was revealed that Fen-Phen was more effective when used During for long periods of time and it reduced the chances of immediate side effects. One of the only reported negatives at this point was that once the medication was ceased, the onset of weight gain ap- parent. BMI CHART 1997 24 Cases of Heart Valve Disease - In '97, at the demand of the FDA, Fenlura- mine and Dexfenfluramine were removed PHENTERMINE PRESCRIBED TO PATIENTS DIAGNOSED AS OBESE from the market due to a surprising twenty-four reporte of heart valve dis- ease. What's probably more surprising is that according to a Mayo Clinic report, roughly 30% of usere ended up having UNDERWEIGHT BMI OF 18.5 OR LOWER abnormal heart valve iesues. 2010 - Jul. 15 NORMAL BMI OF 18.5 - 24.9 Voted Against Approval of Qsymia - Qaymia, previously known a8 Gnexa, consists of Phentermine and Topiramate and is the lateet Phentermine approval (see July 17, 2012). Qaymia, was first reviewed in 2010 but approval was de- clined by the FDA's Endocrinologic & Metabolic Drugs Advisory Committee. OVERWEIGHT BMI OF 25.0 - 29.9 OBESE BMI OF 30.0 - 39.9 2012 - Feb. 22 Qsymia Reconsideration - The committee voted in favor of approval (22-2) for Qsymia. EXTREMELY OBESE BMI OF 40 OR HIGHER • 2012 - Jul. 17 Qsymia approved by FDA - Five months later, the Food and Drug Administration approved the sale of Qyemia in the U.S. 1997 24 CASES OF HEART VALVE DISEASE FROM FEN-PHEN QSYMIA = PHENTERMINE + TOPIRAMATE 2010 2012 2013 15 22 (17 FE RY JULY JULY Qsymia DENIED FDA approval Qsymia Reconsideration vote in FAVOR of Qsymia approval APPROVED by FDA a MyPhentermine.com Rx Weight Loss Information Sources: http://www.drugs.com/pro/phentermine.html http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm312468.htm http://en.wikipedia.org/wiki/Phentermine#History http://www.webmd.com/a-to-z-guides/body-mass-index-bmi-for-adults http://en.wikipedia.org/wiki/Talk%3AFen-phent http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetylnformationforPatientsandProviders/ucm1 80082.htm © Copyright 2012 MyPhentermine.com. All rights reserved.