GHRP 6 - One of the Most Successful Growth Peptides of All Time Infographic

GHRP-6 ONE OF THE MOST SUCCESSFUL GROWTH PEPTIDES OF ALL TIME NH2 FIRST SYNTHESIZED IN 1984 HN HN NH2 His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 GHRP-6 IS SOMETIMES CALLED GROWTH HORMONE RELEASING HEXAPEPTIDE SYNTHETIC PARTIAL ANALOG OF GHRELIN, A PEPTIDE SIGNALING HORMONE AND GROWTH HORMONE SECRETAGOGUE GHRP-6 IS A ROBUST HEXAPEPTIDE THAT IS UNLIKE SERMORELIN WHICH IS A FRAGILE 44 AMINO ACID ANALOG OF ENDOGENOUS HYPOTHALAMIC GHRH GHRP-6 IS NOT FDA-APPROVED AND THERE IS LITTLE APPARENT INTEREST IN PUSHING IT THROUGH THE APPROVAL PROCESS THERE ARE SO-CALLED "ORALLY ACTIVE" ANALOGS OF GHRP-6 (IBATAMOREN/MK-677, MACIMORELIN) CURRENTLY UNDER REVIEW HYPOTHALAMUS PITUITARY GLAND AND GHRP-6 ANTERIOR PITUITARY POSTERIOR PITUITARY Specialized pituitary cells that product, store, and release GH are known as somatotropes. PITUITARY GLAND During typical aging as well as some pathological processes, GH release decreases but the amount of stored GH in somatotropes remains fairly constant throughout the lifespan. The amount of GH actually stored in somatotropes exceeds the amount regularly released in adults, particularly aging adults. GHRP-6 INDUCES GH RELEASE OTHER EFFECTS OF GHRP-6 INCLUDE TISSUE-SPECIFIC ANTIOXIDANT ACTION MEDIATED BY THE ERK1/2 AND PI3K/AKT PATHWAYS INCREASES SLEEP VOLUME INCREASES HUNGER AND FOOD INTAKE - Lacks opioid activity but are potential stimulators of GH release - Has some elevating effect on prolactin and cortisol - May re-stimulate the natural production of GH partly by inhibiting the release of somatostatin. This could help patients who lack natural GH production due to long term synthetic GH abuse - Elevated GH secretion also leads to the liver secreting more anabolic IGF-1 (Insulin-Like Growth Factor 1). - Other claimed benefits of GHRP-6 include an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. FUTURE USES OF GHRP-6 GHRP-6 maybe helpful for treating chronic illness, wasting states and other critical disease states. This could benefit cancer patients, advanced AIDS patients, burn victims and long-term hospitalized patients Also may help treat somatopause (decreased GH levels due to normal aging). SOURCES: http://en.wikipedia.org/wiki/Growth_hormone_releasing_hexapeptide http://biology-forums.com Berlanga J, Cibrian D, Guevara L, Dominguez H, Alba JS, Seralena A, Guillén G, López-Mola E, López-Saura P. Rodriguez A, Perez B, Garcia D, Vispo NS. Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction. Clin Sci (Lond). 2007 Feb;112(4):241-50. Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth homone, ACTH and cortisol release in normal man. Neuroendocrinology. 1995 May,61(5):584-9. Gahete MD, Durán-Prado M, Luque RM, Martinez-Fuentes AJ, Quintero A, Gutiérrez-Pascual E, Córdoba-Chacón J, Malagón MM, Gracia-Navarro F, Castaño JP. Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology. Ann N Y Acad Sci. 2009 Apr;1163:137-53. doi: 10.11114.1749- 6632.2008.03660.x. Hersch CH and Merriam RM. Growth hormone (GH)-releasing hormone and GH secretagogues in nomal aging: Fountain of Youth or Pool of Tantalus? Clin Interv Aging. 2008 March; 3(1): 121-129. Kineman RD, Luque RM. Evidence that ghrelin is as potent as growth hormone (GH)-releasing hormone (GHRH) in releas- ing GH from primary pituitary cell cultures of a nonhuman primate (Papio anubis), acting through intracellular signaling pathways distinct from GHRH. Endocrinology. 2007 Sep:148(9):4440-9. Epub 2007 May 31. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov:139(5):552-61. Veldhuis JD and Bowers CY. Integrating GHS into the Ghrelin System. Int J Pept. 2010; 2010: 879503. Wahlestedt C and Heilig M, Neuropeptide Y and Related Peptides. Psychopharmacology - 4th Generation of Progress. (Published 2000, revised 2008, accessed 12 Feb 2013