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The History of Genetics

The History GENETİCS molecular biological statistics study of genes biochemistry biologu The Founding Fathers PANGENESIS Hippocrates was known as the father of medicine who believed in the inheritance of acquired characteristics. He devised the hypothesis known as pangenesis. He postulated that all organs of the body of a parent gave off invisible "seeds," which were like miniaturized building components reassembling themnsel ves in the mother's womb to form a baby 17th and 18th centuries Aristotle Emphasized the importance of blood in heredity. He thought that the blood supplied generative material for building all parts of the adult body. Jean-Baptiste Lamarck Scientists using the newly developed microscopes imagined that they could see miniature replicas of human beings inside sperm heads. Invoked the idea of "the inheritance of acquired characters." Charles Darwin NATURAL SELECTION 00 Authored The Origin of Species' and hypothesized on how species variability was developed through research with Wallace. Alfred Russel Wallace Postulated the theory of evolution by natural selection. イ → 人 Darwin provided evidence that humans and animals shared a common ancestry. 20th Century Gregor Mendel Performed experiments on inheritance and genetics of sweetpea plants. Ernst Haeckel Haeckel predicted that the heredity material was located in the nucleus. Mid 20th Century 1920-1950: DNA was determined to be the genetic material. 1960S: The DNA code was discovered. DNA GENE AMINO ACID Late 20th century and early 21st century Various advances in technologies of molecular biology, recombinant DNA technology, and biotechnology methods Radioactive or fluorescent tags during this time. Methods of radiolabelling of the DNA for devel- opment of diagnostic and therapeutic methods as well as re- search tools were developed. were discovered Restriction enzymes were discovered and used to construct recombinant DNA molecules that contained foreign DNA that could be grown in abundance in bacterial strains. PCR (Polymerase chain reaction) and host of other biotechnol- ogy methods and new applications were found in medicine, pharmacotherapeutics as well as research. Future Research DEOID GWAS SNP DOIDX [Genome wide association studies] This method (Genome-wide association study) searches the genome for small variations, called single nucleotide polymorphisms or SNPS (pronounced “snips"), that occur more frequently in people with a particular disease than in people without the disease. Epigenetics The development and maintenance of an organism is orchestrated by a set of chemical reactions that switch parts of the genome off and on at strategic times and locations. Epigenetics is the study of these reactions and the factors that influence them. Epigenetic inheritance We used to think that a new embryo's epigenome was completely erased and rebuilt from scratch. But, some epigenetic tags remain in place as genetic information passes from generation to genera- tion. The Human How a baby develops from a single cell How the human brain works GENOME DXIX PROJECT How genes coordinate the functions of tissues How disease predisposition OCCurs and organs The Human Genome Project (HGP) was devoted to developing new and better tools to make gene hunts faster, cheaper and practical for almost any scientist to accomplish. Sources: henp// priwn Ntheathistoreod Genetics.aspK epo/www.hews-medica http// http//ghtnlm.nihgowhandbook/genomicresearch/gwastudies ep/ common variant.pdf Npeam.genetics.utah. on00325, icvnberacel o100011 http://www.genome. labroots Your Science Network 8)

The History of Genetics

shared by akshaymasand on Apr 08
What makes humans, human? Let’s put aside all philosophical and moral debate, and focus on our genetic structure. Humans are human based on our hereditary information, or in other words, our genome....




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