Hippocampal Anatomy and Cell Morphology

Anatomy of the Hippocampus CA1 temporoammonic pathway Schaffer collaterals subgranular zone granular cell layer recurrent collaterals lateral perforant pathway II mossy fibers || hilus > associational commisural pathways САЗ medial perforant pathway DG Hippocampal cell morphology 1mm 100µm granule cell (+) 500µm ахon dendrite r basket cell (-) stratum moleculare (external) stratum moleculare (medial) hilar mossy cell (+) stratum moleculare (internal) stratum granulosum subgranular zone stratum lacunosum-moleculare stratum radiatum stratum pyramidale stratum oriens CA3 pyramidal cell (+) OLM interneuron (-) "giant" cell (+) trilaminar interneuron (-) perforant path-associated interneuron (-) CA1 pyramidal cell (+) Schaffer collateral-associated cell (-) Hilar Interneurons МОРР сell Sources 1. Cope DW, Maccaferri G, Márton LF, Roberts JDB, Cobden PM, Somogyi P: Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones HIPP cell 9. Seri B, García-Verdugo JM, Collado-Morente L, McEwen BS, Alvarez-Buylla A: Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. J Comp Neurol 2004, 478:359–78. 10. Gulyás a I, Tóth K, McBain CJ, Freund TF: Stratum radiatum giant cells: a type of principal cell in the rat hippocampus. Eur J Neurosci 1998, 10:3813–22. target different domains of pyramidal cells in the CA1 area of the rat hippocampus. Neuroscience 2002, 109:63-80. 2. Buckmaster PS, Wenzel HJ, Kunkel DD, Schwartzkroin P a: Axon arbors and synaptic connections of hippocampal mossy cells in the rat in vivo. J Comp Neurol 1996, HICAP cell 11. Svoboda KR, Adams CE, Lupica CR: Distinct Classes of Hippocampal Interneurons. 1999, 19:85–95. 366:271-92. 3. Sahay A, Hen R: Adult hippocampal neurogenesis in depression. Nat Neurosci 2007, 10:1110–5. 12. McQuiston a R, Madison D V: Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus. J Neurosci 1999, 19:2887–96. 4. Kerr AM, Capogna M: Unitary IPSPS enhance hilar mossy cell gain in the rat hippocampus. J Physiol 2007, 578(Pt 2):451–70. 13. Vida I, Halasy K, Szinyei C, Somogyi P, Buhl EH: Unitary IPSPS evoked by interneurons at the stratum radiatum stratum lacunosum-moleculare border in the CA1. hilar mossy cell 5. Fuentealba P, Begum R, Capogna M, Jinno S, Márton LF, Csicsvari J, Thomson A, Somogyi P, Klausberger T: Ivy cells: a population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocam- pal network activity. Neuron 2008, 57:917–29. 1998:755–773. 14. Fukazawa Y, Saitoh Y, Ozawa F, Ohta Y, Mizuno K, Inokuchi K: Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 2003, 38:447–60. basket cell 6. Spruston N: Pyramidal neurons: dendritic structure and synaptic integration. Nat Rev Neurosci 2008, 9:206–21. 15. Chittajallu R, Kunze A, Mangin J-M, Gallo V: Differen- tial synaptic integration of interneurons in the outer and inner molecular layers of the developing dentate gyrus. J Neurosci 2007, 27:8219–25. 7. Freundl TF: Interneurons of the Hippocampus. 1996, 470. 8. Leroy C, Poisbeau P, Keller a F, Nehlig A: Pharmacologi- cal plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy. J Physiol 2004, 557(Pt 2):473–87. 16. Cameron H a, McKay RD: Adult neurogenesis produc- es a large pool of new granule cells in the dentate gyrus. J Comp Neurol 2001, 435:406–17. dendrite ахon