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The Genetics of Being a Morning Person

23andMe Are you a Morning Person or Night Owl? 23andMe explores the difference. 44% 56% of 23andMe research of 23andMe research participants consider themselves morning people. participants consider themselves night owls. <30 A>60 Women are more 63.1% of those likely to be morning people than night owls. 24.2% of those under 30 years old prefer mornings. over 60 are morning people. If dad is a morning person, his daughter has 2.4x higher odds of being a morning person; and his son has 1.9x higher odds of being a morning person. Differences in circadian rhythm have been associated with medically relevant traits like sleep, obesity and depression. Morning people are significantly less likely to have insomnia. 20.9% of morning people vs. 39.7% of night people Morning people are also... ..less likely to sleep soundly ..less likely to require more than 8 hours of sleep per day 43.4% 50.7% 53.6% 58.0% ..less likely to sweat while sleeping ..less likely to sleep walk 27.1% 7.1% 31.7% 9.1% 23andMe identified 15 locations (loci) in our DNA that are significantly associated with being a morning person. 7 of those are near genes that have an established connection to circadian rhythm. 3 of these genes are: MAN zZ HCRTR2 mutations of this gene have been linked to narcolepsy in dogs and humans FBXL3 VIP this gene has been found to prolong REM sleep in rabbits mutations of this gene were shown to have an extended circadian period Morning people are more likely to pair with night owls. SOURCES: To identify genetic variants associated with being a morning person, 23andMe conducted a genome-wide association study (GWAS) of self-reported morningness, followed by analyses of biological pathways and other phenotypes in 89,283 individuals of European descent. Paternal trait correlations were calculated by looking at traits among a group of 15,000 couples with children who are 23andMe customers. The likelihood that morning people pair with night owls was based on a logistic regression analysis of 2,095 couples with children, controlling for age and population structure. Data for this study was contributed by 23andMe customers who provided informed consent to take part in this research under a protocol approved by the AAHRPP-accredited institutional review board, Ethical and Independent Review Services. Data collected by November 2013. Mignot, E. et al. Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment. Proc Natl Acad Sci USA 88, 3475-3478 (1991). Lin, L. et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365-376 (1999). Godinho, S. I. et al. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science (80-. ). 316, 897-900 (2007). Obal Jr., F., Opp, M., Cady, A. B., Johannsen, L. & Krueger, J. M. Prolactin, vasoactive intestinal peptide, and peptide histidine methionine elicit selective increases in REM sleep in rabbits. Brain Res 490, 292-300 (1989). 23andMe identified 15 loci that are significantly associated with being a morning person. 7 of those are near genes that have an established connection to circadian rhythm, including: RGS16, VIP, PER2, HCRTR2, RASD1, PER3 and FBXL3

The Genetics of Being a Morning Person

shared by 23andMe on Feb 20
Are you a morning person or a night owl? 23andMe research shows that more than 60% of people over 60 are morning people. Women are also more likely to be early risers.



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