Things To Know About Diabetes

Things To Know About Diabetes TYPES OF DIABETES ΤΥΡE 1 TYPE 2 10% 90 % OF CASES OF CASES is partly inherited, and then triggered by certain infections is due primarily to lifestyle factors (especially a diet high in sugars) and genetics. Recycling Of Nucleoside Transporters In Cells From Gestational Diabetes Mellitus (GDM) In (GDM) The recycling of HENT1 is reduced, thus limiting its availability at the plasma membrane. ENT 1 in cells from normal pregnancies results in a physiological expression ADO ADO This phenomenon leads to reduced HENT1-mediated uptake of adenosine of the gen SLC29A1 (coding for HENT1) leading to synthesis of these proteins which are then targeted to the plasma membrane. (dotted arrow) GDMassociated increased (1) nitric oxide ENTI ENTI Once in the plasma membrane (NO) synthesis coukd be responsible of this phenomenon via a mechanism that includes activation of transcription factors HENT1 function is to take up adenosine (ADO) ADO ! acting as down-regulators of SLC29A1 promoter activity and expression. ADO From data in references (83,84,96,97) omicsonline.org ↑ NO SLC29A1, SLC29A1 Intracellular NORMAL PREGNANCY GESTATIONAL DIABETES MELLITUS (GDM) Gestational Diabetes Mellitus (GDM) Resembles Type 2 Diabetes In Several Respects 2 % -5 % ALL PREGNANCIES AND MAY IMPROVE OR DISAPPEAR AFTER DELIVERY 20 % - 50 % AFFECTED WOMEN DEVELOP TYPE 2 DIABETES LATER IN LIFE A 2008 Study completed in the U.S. found the number of American women entering pregnancy with pre-existing diabetes is increasing. The rate of diabetes in expectant mothers has more than doubled in the past six years SIGNS & SYMPTOMS Central Respiratory - Kussmaul Breathing - Polydipsia -Polyphagia - Lethargy - Stupor (hyper-ventilation) Systemic - Weight Loss Eyes -Blurred Vision Breath Urinary - Polyuria - Glycosuria - Smell of Acetone Gastric - Nausea - Vomiting - Abdominal Pain Overview Of The Most Significant Symptoms Of Diabetes Classic symptoms of untreated diabetes v Loss of weight v Polyuria (frequent urination) v Polydipsia (increased thirst) * Polyphagia (increased hunger) * Blurred vision is a common çomplaint leading to a diabetes diagnosis. Anumber of skin rashes that can occurin diabetes. Reference Data: http:/len.wikipedia.org/wik/Diabetes melitus