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Obesity is Gluttony Narrative

METABOLIC SYNDROME nature, medicine Abnormal hedonic response Abnormal satiety Abnormal homeostatic response Definition (IDF): Central obesity (usually BMI > 30 kg/m2), plus 2 of the following: - TGs > 150 mg/dL - HDL < 40-50 mg/dL ↑ blood pressure - hyperglycemia Food intake >> energy needs Abnormal nutrient sensing Abnormal central regulation of systemic metabolism: - Disrupted endocrine hormone axis (HPT) Dysregulated efferent autonomic nervous system Abnormal liver function: Systemic glucotoxicity Hepatic glucose output ↑ Glucose uptake 11 (& conversion into lipids) Fatty acid uptake 11 (& T conversion into TGs and Fatty liver disease Dysregulated afferent autonomic nervous system VLDL and their release into Heart disease the blood stream) Pre-diabetes, followed by overt diabetes Pancreatic islet mass T, followed by exhaustion Pancreatic hormones: Glucagon 1 Insulin T (but with resistance): Dietary nutrients 11 Abnormal gastrointestinal activity: - Dietary fats & sugar absorption T -Gut motility T - Alterations in gut microflora, Gut hormones: CCK Ghrelin PPY ECs ↑ GLP-1 1 Incretin action t: contributing to metabolic disease stimulates insulin release - inhibits glucagon release - increases insulin sensitivity - effects on gut motility GIP Systemic low-grade inflammation Abnormal visceral adipose tissue function: r- Glucose uptake Net result: (& conversion into lipids & I Anti-inflammatory & 11 pro-inflammatory cytokines stored as fat) Increased fat storage & fat tissue hypertrophy Lipid uptake 1↑ (& stored as fat) - Lipolysis ↑ (release of fatty acids into Adipose tissue hormones: Leptin T (but with resistance) satiety I energy expenditure immune dysregulation angiogenesis dysregulation subfertility bone dysfunction -Adiponectin gluconeogenesis ↑ glucose uptake t insulin sensitivity + body weight 1 Systemic lipotoxicity the blood stream) Abnormal muscle function: Glucose uptake Fatty acid uptake 11 Complications of Chronic Diabetes: - chronic kidney disease endothelial function - cardiovascular disease - peripheral nerve damage - eye disease & blindness - non-healing skin ulcers, usually leading to amputations - non-alcoholic fatty liver disease, which can lead to cirrhosis OVERVIEW

Obesity is Gluttony Narrative

shared by kcatoto on Jan 27
Yes, excess dietary intake leads to obesity, which in turn fuels metabolic syndrome, but the use of multiple large pieces of chocolate cake to represent intake just stokes the fire of weight bias and ...


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