Growing resistance to last-line antibiotics

Growing resistance to last-line antibiotics Carbapenems are a major last-line class of antibiotics to treat bacterial infections. The spread of carbapenem-resistant infections is a threat to healthcare and patient safety in Europe as it seriously curtails the ability to cure infections. Each year, 30 EU/EEA countries report data on antimicrobial resistance to the European Antimicrobial Resistance Surveillance Network (EARS-Net) and on antimicrobial consumption to the European Surveillance of Antimicrobial Consumption network (ESAC-Net). Both networks are hosted at ECDC. For the first time, 18 countries reported data on Acinetobacter spp. to EARS-Net. In addition, experts in 38 European countries participated in the European Survey on Carbapenemase-Producing Enterobacteriaceae (EUSCAPE) done for ECDC by the University Medical Centre Groningen, The Netherlands. Carbapenems are one of doctors' last possible choice of antibiotics to treat infections due to bacteria resistant to multiple antibiotics. Carbapenem consumption in hospitals 8. countries reported a significant countries reported a significant increase decrease 25.3% Fluoroquinolones 25.7% Third-generation cephalosporins 49.3% Fluoroquinolones Klebsiella pneumoniae EU-mean resistance Acinetobacter spp. EU-mean resistance 44.6% Aminoglycosides 6.2% Carbapenems 22.2% Aminoglycosides Still low but increasing. 39.3% Carbapenems Limited options left for treatment. 2013 7/30 Enterobacteriaceae (CPE) - Epidemiological stages 2010 Enterobacteriaceae (CPE) - Epidemiological stages 3/30 4/30 3130 2013 Nr. of countries / Countries surveyed O No case Sporadic occurrence Single hospital outbreak O Sporadic hospital outbreaks • Regional spread O Inter-regional spread 3/30 5/30 Endemic situation nase-producing Acinetobacter baumannii (CRAB) - Epidemiological stages 13/38 25/38 Many EU countries lack guidance on prevention and control of carbapenem-resistant infections. countries reported an uncertain countries reported a certain stage stage 2/13 19/25 2/38 15% 76% of these countries have guidance on infection control measures on CPE 5% of these countries have guidance on infection control measures on CPE of all countries have guidance on infection control measures on CRAB Infection control measures prudent antibiotic perform surveillance and isolate patients use cohort nursing by separate, dedicated team and equipment Everyone is respensible. Use antibiotics prudently! hygiene precautions Carbapnem- resistant a 2/30 3/30 Carbapenems