Generic vs. Brand Name Drugs: The Outlook 2014-2016

Generic VS. Brand Name Drugs The Outlook 2014-2016 With more and more popular brand name drugs losing their patent protection in 2014, the generic vs. brand name debate is gaining momentum. What are the differences between brand name and generic drugs? What drugs will be losing their patent protection in the next few months/years? Find out the answers to these questions and more below. The Market Share The global generic pharmaceutical market is expected to reach Spending on Branded Drugs vs. Generic Drugs *Figures 2012 $156.9 Generic Drugs (branded and unbranded): 28.5% billion by Branded Drugs: 71.5% 2016 84% 87% Generics' Share of in in Prescriptions 2012 and will likely rise to 2017 Facts and Figures The pharmaceutical market will reach nearly Nearly 8 in 10 prescriptions filled in the U.S. are for generic drugs. Drugs with nearly $100 billion in U.S. sales are expected to lose patent protection between 2011 and 2015. $1,200 billion ENT by 2016 PATENT ED TEN On average the cost of a generic drug is 80-85% less than its brand-name counterpart. Generic drug The U.S. has the world's largest generics market at 45% brand-name counterpart The average cost of researching and developing a new medicine is claimed to be approximately €1.4 billion. Global generic spending is set to rise from $242 billion in 2011 $400-$500 billion by 2016 to How Generic Drugs Enter the Market Step 1. Step 2. Step 3. Eventually that patent expires - allowing another company to They protect that drug brand with a patent that prevents anyone else from selling the active ingredient for a certain period of time. Big pharmaceutical companies spend hundreds of millions PATENTED Generic of dollars to bring a new drug brand to market. make another pill, a generic, with the same active ingredient. ATENT To market Fact! Of the typical 20 year patent period – firms typically only get 8-10 years of effective patent protection before facing generic competition. Generic vs. Brand Name Drugs The Similarities & Differences Ingredients The FDA requires generic drugs to have the same active ingredient and strength as the name brand version. However, they do not need to have the same inactive ingredients as their brand name counterparts e.g. binding materials, preservatives and flavouring agents. Method of Consumption The method of consumption (i.e. how the drug is taken into the body - pill or liquid form) of a generic drug has to be the same as its brand name version. Testing and Packaging The manufacturing, packaging, and testing sites of generic drugs are judged under the same criteria as brand name drugs, and must meet the same specifications. The bioequivalence test checks to see if a generic drug contains the same active ingredients in roughly the same amount. Price The average cost of a generic drug is 80-85% less than then the brand-name counterpart. Branded Generic counterpart Loss of Patent Protection 2013-2016 A Timeline 1, 2013 Oxycontin Use: Pain management Company: Purdue Pharma LP. Sales: $2.8 billion in 2011 Zometa Use: Treatment for hypercalcemia of malignancy caused by high calcium blood levels due to cancer Company: Novartis Sales: $1.5 billion in 2010 ZOMETA 4 mg Puler und Losunp .oo Herstellungerer Intasion Zoledronsure Xeloda Use: An oral chemotherapy treatment for metastatic colorectal and breast cancer Xeloda Capecitabine 150 mg Company: Genentech/Roche Sales: $647.6 million in 2011 O 60 film-coated tablets Lantus insulin glargine (rDNA origin) injection 100units/mL U-100) Lantus 2014 Use: For the treatment of diabetes Company: Sanofi Sales: $6.12 billion FOR USE ONLY IN OPTICLIK INSULIN DELNERY DEVICE Nexium 40mg Nexium. Use: For the treatment of gastroesophageal reflux disease (GERD) Company: AstraZeneca Sales: $4.9 billion in 2010 For Delayed-Release Oral Suspension Cymbalta Use: For the treatment of depression, generalized anxiety disorder, diabetic nerve pain, fibromylagia and chronic musculoskeletal pain Company: Eli Lilly Sales: $4 billion in 2011 Cymbalta' daloxetine HÇI Ca 60 Celebrex PRESCRIPTION ONLY MEDICINE Use: For the treatment of osteoarthritis and rheumatoid arthritis symptoms and management of acute pain in adults Company: Pfizer Sales: $2.5 billion in 2011 CELEBREX, 200 mg ecads capde STORE UPRIGHT Symbicort Use: For asthma and COPD Symbicort 80/4.5 Company: AstraZeneca Sales: $3.1 billion in 2011 budesonide 80 mcg/formoterol fumarate dihydrate 4.5 mcg INHALATION AEROSOL 20 TABLETS TA 4165 Evista EVISTA Use: For treating and preventing osteoporosis Company: Eli Lilly Sales: $1.3 billion in 2010 60 mg film coated tablets ralouifene hydrochloride Actonel Use: For the prevention and treatment of osteoporosis Company: Warner Chilcott Sales: $1.6 billion in 2010 Once a Week Actonel 35 mg risedronate sodium film-coated tablets Abilify Use: An anti-psychotic used to treat the symptoms of schizophrenia and bipolar disorder Company: Otsuka Pharmaceutical Sales: $4.6 billion in 2010 2015 ABILIFY 10 mg (aripiprazol) 28 Tabletten SINGLE-USE PRE-FILLED SYRINGES Copaxone Use: A treatment for relapsing-remitting multiple sclerosis Company: Teva Pharmaceuticals Sales: $3.57 billion in 2011 COPAXONE (glatiramer acetate injection) Contains 30 single use PRE-FILLED Syringes andAhel es dab STORAGE CONDTIONS: KEEP REFRIGERATED (36462O AND PROTECTEO FROM UGHT Gleevec Use: A treatment for chronic myeloid leukemia (CML)and gastrointestinal stromal tumor (GIST) Gleevec Company: Novartis Sales: $4.26 billion in 2010 100 Advodart Use: A treatment for benign prostatic hyperplasia (enlarged prostate gland) Company: GlaxoSmithKline Sales: $973 million in 2010 Avodart" 0.5 mg Dutasteride Combivent Use: Management of chronic obstructive pulmonary disease (COPD) symptoms Company: Boehringer Ingelheim Sales: $965 million in 2010 Combivent (ipratropium bromide and albuterol sulfate) Inhalation Aerosol 14.7 grams 200 metered actuations Prezista Use: A protease inhibitor for human immunodeficiency virus (HIV) infection Company: Janssen Therapeutics Sales: $888 million globally in 2010 PREZISTA 75 mg darunavir PR PREZISTA 5mg Crestor 2016 Use: A treatment for lowering LDL cholesterol in the bloodstream Company: Astra Zeneca Sales: $6 billion in 2010 CRESTOR rouvastatin calcium Benicar Benicar Olmesartan medoxomil Use: High blood pressure Company: Daiichi Sankyo, Inc Sales: $2.5 billion in 2010 20 mg Via Oral Tabletas Recubiertas The Top 10 Prescribed Medicines for 2013 (Q4) The following is a list of the top 10 prescribed medicines by U.S. National Sales in Q4 2013. Figures include sales through both retail and hospital channels, listed by drug name and sales value in U.S. dollars. Rank Drug Sales ($000) Abilify 1,602,329 Otsuka Pharmaceutical Co. Nexium 1,536,435 AstraZeneca Pharmaceuticals Humira 1,461,861 AbbVie. Inc. Crestor 1,333,502 AstraZeneca Pharmaceuticals Advair Diskus 1,247,330 GlaxoSmithKline Enbrel Amgen Inc. 1,189,844 Cymbalta Eli lilly and Company 1,064,186 Remicade 8. 994,020 Centocor Ortho Biotech, Inc Neulasta 9. 854,508 Amgen Inc. 10 Сорахоne 851,351 Teva Pharmaceuticals Who Stands to Lose in 2014? 10 These big pharma companies each make at least $6 billion in revenue from drugs going off patent in 2014. Here is how $8.1 much revenue is at stake from $7.7 lost patents. $7.2 $6.7 $6.0 6. 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