Caffeine + L-theanine: Better Together

CAFFEINE + L-THEANINE CAFFEINE L-THEANINE 4 3 Cognitive Effects -4 -5 -6 Placebo Caffeine Control 0.4 mg/kg 2 mg/kg 10 mg/kg Caffeine improves rapid visual information processing (RVIP) accuracy and digit vigilance reaction time [1] L-theanine increases brain derived neurotrophic factor (BDNF), which is crucial for learning, memory, and resilience to stress [2] THE ULTIMATE SYNERGY Change in deoxyhemoglobin (mumol/L) Caffeine + L-theanine improves simple reaction time [1] -5 -1 Placebo Caff L-thea Caff+L-thea -10 -15 L-theanine abolishes caffeine's suppression of cerebral blood flow [3] -20 -25 Placebo Caff L-thea Caff+L-thea L-theanine + caffeine together improve attention more than caffeine alone. L-theanine reduces the negative effects of caffeine like anxiety, increased blood pressure, and insomnia. [1] Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. 2008;77(2):113-22. SOURCES: [2] Wakabayashi C, Numakawa T, Ninomiya M, Chiba S, Kunugi H. Behavioral and molecular evidence for psychotropic effects in L-theanine. Psychopharmacology (Berl). 2012;219(4):1099- 109. [3] Dodd FL, Kennedy DO, Riby LM, Haskell-ramsay CF. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology (Berl). 2015;232(14):2563-76. RVIP accuracy BDNF