The Land of Milk, Honey & Life Sciences

A LAND OF A LAND OF INNOVATION AND GROWTH A LAND OF RECORD BREAKING MILK, HONEY AND 1" 1000 life sciences companies Quality of scientific research institutions Medical Device patents per capita LIFE SCIENCES 60+ new companies formed each year Venture capital availability (all industries) 40% of companies established in the last 6 years Or Making the Planet Healthier, One Product at a Time 4 BioPharma patents per capita Global scientific publications per capita $8B+ annual life science exports A LAND OF INTELLECTUAL PROPERTY A LAND OF DIVERSE MEDICAL INNOVATIONS Operating in All Walks of Life Sciences ISRAEL 16 ISRAEL 18 NTED STATES NO, OF NO. OF MEDICAL DEVICES BIOPHARMA Life Science Industry by Sector (1026 Companies) PATENTS PATENTS PER MILLION CAPITA PER MILLION CAPITA Biotechnology Healthcare IT AGBiotech 19% 7% 2% Pharmaceuticals 11%. Other 4% Medical Devices 57% ISRAEL 18% % OF TOTAL LIFE SCIENCE PATENTS GRANTED REST OF THE WORLD 82% Medical Devices Companies Imaging Other 15%. 10% Medical Equipment 18% "Israel lives on its brain. This is not a one-time thing, it is something renewed constantly and ever more powerfully." A LAND OF MERGERS AND ACQUISITIONS Diagnostic 14% Disposable & Implantable 43% Shimon Peres, Israel's President PRICE (SM) 346 300 YEAR COMPANY ACQUIRED ACQUIRER Oridion superDimension Poly Touch Medical Covidien Covidien "The current decade will create many successes in the life sciences field, similar to those we saw in communications and IT in the previous decade" Covidien 40 2. NA 90 ConTipi Ltd. OIS Inc. Beeologics Ltd. 30 Biotech Companies Pharmaceutical Companies Merge Healthcare Monsanto Co. Ruth Alon and Dr. Benny Zeevi. Co-Chairpeople of ILSI conference 190 Antibody, Immunotherapy & Vaccines 11% Natural Drug Delivery Drug Discovery 26% New Chemical Entity 16% Align Technology Inc. PhotoMedex Inc. Cadent Inc. Other Pharmaceuticals & Biogenerics 14% 18% Materials 10% Generic Drugs 11% 45% Radiancy Inc. Technologies Ltd. Optonol 175 Other Diagnostic Kits 13% Abbott Laboratories Labolaio Alcon Inc. "The Israeli life sciences sector has a strong track record of innovation and commercial success, and presents and opportunity for further growth from what is currently a more mature base." 19% StarLIMS 123 Tissue Engineering & Cell Therapy 180 I Ltd. Shamir Optical Industry Medingo LabCoat Ry 17% Essilor 130 Roche Scientific 160 Jonathan Silverstein, Orbimed Advisors Boston 100 Bioline Rx (Licensing) Ventor y Ikaria Holdings Medtronic 282 325 "Israel is like the Silicone Valley of Biomed" Omrix AlphaBioTech Mediguide CMT Medical Johnson & Johnson 447 Israel Makov, Chairman of Given Imaging Nobel Biocare 95 300 30 42 St. Jude Medical 8. Thales SA Versamed GE Healthcare BUILDING CLUSTERS OF KNOWLEDGE (no. of companies) 150 75 Candela Inolase NESS Bioness Remon Medical Boston Scientific 80 30 454 Ester Neurosciences Amarin Taro Pharmaceutical Sun Pharmaceuticals nammaceu. Dentsply AMS 100 Uri-Dent Medimpulse Colbar 50 Johnson & Johnson 159 Colbar Disc-O-Tech 220 Kyphon Predix Pharmaceuticals DIAGNOSTICS HEALTHCARE IT 90 IMAGING DRUG DELIVERY MIS MONITORING Epix 50+ milestones Stryker TA Associates SightLine 125 110 60 50 50 40 Alma Lasers 90 * January to April 2012 TARGETING MAJOR DISEASE AREAS (% of companies) Internal Medicine Dermatology & Aesthetics Oncology Neurology & Psychology Opthalmology Cardiovascular Orthopedic Oral & Dental Gastroenterology 23 12 0% 5. % SOURCES Reports: Articles: • http://www.hayadan.org.il/biomd-2012-interview-110512/ • Israel's Life Science Industry http://www.export.gov.il/uploadfiles/04 2012/life%20science %20industry%20in%20numbers%202011%20-%20final.pdf • International M&A http://www.investinisrael.gov.il/NR/exeres/ • http://www.globes.co.il/serveen/globes/docview.asp?did B73BF18C-34C3-4410-BE93BB2A26.htm =1000648015&fid=1725 • The Israeli Life Science Industry (Profile by ILSI) http://www.ilsi.org.il/industry_profile.asp • Shizim Newsletter. Courtesy of Yossi Bornstein http://app.activetrail.com/S/ziezxeweefd.htm • http://www.globes.co.il/serveen/globes/docview.asp?did =1000743464& fid=1725 CadenSee Let's Talk Medical • Life Sciences in Israel http://www.inveinisrael.gov.il/NR/rdonlyres/6A79963B-47BC- 4330-9ACD-A54D06EA9E9E/0/LifeSciencesoverview2011.pdf • http://www.globes.co.il/news/article.aspx?did=1000558733 www.cadensee.com